Understanding and treating skin-related side effects from immune therapies
Official title: Mechanistic Assessment and Treatment of Immune Related Adverse Events
Funded at Portland VA Medical Center · NIH-11053214 · Data updated 2026-11-12
This study is looking at skin side effects that some cancer patients experience from new immune therapies, and it aims to understand how certain immune cells in the skin cause these issues so that better treatments can be developed to help manage them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| NIH project number | 1I01CX002750-01A2 |
| Project ID | NIH-11053214 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients undergoing immune checkpoint blockade therapy who are experiencing or at risk of developing skin-related adverse events.
✕Less likely to help
Patients who are not receiving immune checkpoint blockade therapies or who do not experience skin-related side effects may not benefit from this research.
What this research studies
This research focuses on immune-related adverse events (irAEs) that occur as a result of immune checkpoint blockade therapies, which are increasingly used in cancer treatment. It aims to improve the understanding of these side effects, particularly dermatologic toxicity, by investigating the role of specific immune cells in the skin. The study will analyze how these immune cells contribute to skin-related adverse events and develop targeted treatment strategies to manage these effects. By doing so, the research seeks to enhance the safety and effectiveness of immunotherapy for patients.
Why it matters
Potential benefit: If successful, this research could lead to better management of skin-related side effects from immunotherapy, improving patient comfort and treatment outcomes.
How similar studies have gone: Previous research has shown promising results in understanding and managing immune-related adverse events, indicating that this approach has potential for success.
Where this research is happening
-
Portland VA Medical Center
Portland, United States Active
Researchers
- Principal investigator: Kulkarni, Rajan P. — Portland VA Medical Center
- Study coordinator: Kulkarni, Rajan P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.