Understanding and treating preeclampsia through protein and autophagy targeting
Official title: Targeting proteinopathy/tauopathy and impaired autophagy for mechanistic understanding and therapeutic intervention of preeclampsia
Funded at University of Texas Med Br Galveston · NIH-11095976 · Data updated 2026-11-12
This study is looking into how preeclampsia, a serious pregnancy issue, might be linked to Alzheimer's disease, with the goal of finding new treatments that help both moms and babies by fixing the root problems instead of just treating the symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | June 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $489,400 |
| NIH project number | 5R01HD110408-02 |
| Project ID | NIH-11095976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals who develop hypertension and proteinuria after 20 weeks of gestation.
✕Less likely to help
Patients who are not pregnant or those who do not develop preeclampsia will not benefit from this research.
What this research studies
This research investigates the mechanisms behind preeclampsia, a serious pregnancy complication characterized by high blood pressure and protein in the urine. It explores the connection between preeclampsia and Alzheimer's disease, focusing on how protein aggregation and impaired cellular processes contribute to the condition. The study aims to develop targeted therapies that can improve outcomes for mothers and their babies by restoring normal cellular functions and reducing harmful protein buildup. Patients may benefit from new treatment options that address the underlying causes of preeclampsia rather than just managing symptoms.
Why it matters
Potential benefit: If successful, this research could lead to effective therapies for preeclampsia, improving maternal and neonatal health outcomes.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in other conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Sharma, Surendra — University of Texas Med Br Galveston
- Study coordinator: Sharma, Surendra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.