Understanding and treating preeclampsia through protein and autophagy targeting
Targeting proteinopathy/tauopathy and impaired autophagy for mechanistic understanding and therapeutic intervention of preeclampsia
['FUNDING_R01'] · UNIVERSITY OF TEXAS MED BR GALVESTON · NIH-11095976
This study is looking into how preeclampsia, a serious pregnancy issue, might be linked to Alzheimer's disease, with the goal of finding new treatments that help both moms and babies by fixing the root problems instead of just treating the symptoms.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS MED BR GALVESTON (nih funded) |
| Locations | 1 site (GALVESTON, UNITED STATES) |
| Trial ID | NIH-11095976 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind preeclampsia, a serious pregnancy complication characterized by high blood pressure and protein in the urine. It explores the connection between preeclampsia and Alzheimer's disease, focusing on how protein aggregation and impaired cellular processes contribute to the condition. The study aims to develop targeted therapies that can improve outcomes for mothers and their babies by restoring normal cellular functions and reducing harmful protein buildup. Patients may benefit from new treatment options that address the underlying causes of preeclampsia rather than just managing symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals who develop hypertension and proteinuria after 20 weeks of gestation.
Not a fit: Patients who are not pregnant or those who do not develop preeclampsia will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective therapies for preeclampsia, improving maternal and neonatal health outcomes.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in other conditions, suggesting potential for success in this novel approach.
Where this research is happening
GALVESTON, UNITED STATES
- UNIVERSITY OF TEXAS MED BR GALVESTON — GALVESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHARMA, SURENDRA — UNIVERSITY OF TEXAS MED BR GALVESTON
- Study coordinator: SHARMA, SURENDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease