Understanding and Treating Organ Damage and Inflammation After Severe Injury
Mechanistic Elucidation and Targeted Therapy of Organ Injury and Inflammation following Trauma
This project aims to discover how severe injuries cause organ damage and inflammation, hoping to find new ways to help patients recover better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11086823 on NIH RePORTER |
What this research studies
Severe injuries can lead to a serious condition called multiple organ dysfunction syndrome (MODS), which is a major cause of death. We believe MODS happens because of a harmful cycle of too much inflammation and problems with blood clotting. While recent medical advances have helped more patients survive the initial injury, they are still at risk for MODS. Our goal is to understand the exact link between these inflammatory responses and clotting issues to develop better treatments. We are particularly focusing on how blood platelets play a central role in this process, called immunothrombosis, after trauma.
Who could benefit from this research
Good fit: This research is relevant for patients who have suffered severe physical trauma and are at risk for complications like multiple organ dysfunction syndrome.
Not a fit: Patients who have not experienced severe physical trauma or are not at risk for MODS would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new targeted therapies that prevent organ damage and improve survival for patients who have experienced severe trauma.
How similar studies have performed: While initial treatments like blood transfusions and tranexamic acid have improved early survival, the specific mechanisms linking inflammation and clotting in MODS are still incompletely understood, making this a novel area of focus.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Neal, Matthew D — University of Pittsburgh at Pittsburgh
- Study coordinator: Neal, Matthew D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.