Understanding and treating NUT carcinoma
Pathogenesis and Treatment of NUT midline carcinoma
This work aims to find new ways to treat NUT carcinoma, a very aggressive cancer, by understanding how it grows.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11110503 on NIH RePORTER |
What this research studies
NUT carcinoma is a highly aggressive cancer that affects people of all ages. We know this cancer is caused by a specific genetic change that creates a protein called BRD4-NUT, which helps the cancer cells grow and multiply. Our previous work showed that certain medications, called BET inhibitors, could slow down this cancer in people, but their effectiveness was limited. Now, we are looking for new ways to target the cancer's growth mechanisms that can work even better when combined with BET inhibitors.
Who could benefit from this research
Good fit: This research is focused on understanding and treating NUT carcinoma, a rare and aggressive form of cancer.
Not a fit: Patients with other types of cancer or those not diagnosed with NUT carcinoma would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more effective and less toxic treatments for patients with NUT carcinoma, improving their chances of survival.
How similar studies have performed: Previous work with BET inhibitors has shown some success in inhibiting NUT carcinoma growth in humans, but this research seeks to find more effective combinations.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: French, Christopher a — Brigham and Women's Hospital
- Study coordinator: French, Christopher a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.