Understanding and treating nasal obstruction and loss of smell
Official title: Novel mechanisms and therapeutic approaches for nasal obstruction and olfactory losses
Funded at Ohio State University · NIH-10890110 · Data updated 2026-11-12
This study is looking into why many adults in the U.S. have trouble breathing through their nose and losing their sense of smell, and it aims to find better ways to treat these issues by understanding how airflow and senses work in the nose.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 26, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $393,750 |
| NIH project number | 5R01DC020302-03 |
| Project ID | NIH-10890110 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 experiencing nasal obstruction or loss of smell due to sinus disease.
✕Less likely to help
Patients with nasal symptoms not related to sinus disease or those under 21 may not benefit from this research.
What this research studies
This research investigates the underlying mechanisms of nasal obstruction and smell loss, which affect millions of adults in the U.S. The team aims to identify how airflow and sensory pathways contribute to these symptoms, using innovative methods to objectively measure and evaluate nasal function. By developing new clinical tools, the research seeks to improve treatment strategies that currently rely on subjective patient feedback. Ultimately, the goal is to enhance patient outcomes through a better understanding of nasal sinus disease.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for nasal obstruction and smell loss, improving quality of life for affected patients.
How similar studies have gone: Previous studies have shown promise in understanding nasal function and sensory pathways, indicating potential for success in this novel approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Zhao, Kai — Ohio State University
- Study coordinator: Zhao, Kai
Related research
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-
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Developing new tests and treatments for adults with chronic nasal blockage and smell loss by studying how airflow and nasal sensing work.
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This study is testing if a combination of a nasal spray and steroids can help people with chronic nasal obstruction who haven't found relief with regular treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.