Understanding and Treating Muscle Loss in Kidney Disease
Protein Nutrition in Experimental Uremia
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11180406
This project aims to discover new ways to prevent and treat muscle weakness and loss in people with long-term kidney disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11180406 on ClinicalTrials.gov |
What this research studies
Many people with chronic kidney disease experience muscle wasting, which can make them weaker and sicker. We are looking into a specific protein pathway, called CRL4ACRBN, that appears to cause muscle protein loss in kidney disease. Our early findings suggest that blocking this pathway could help protect muscles. We are also exploring how a medication called pomalidomide, which can block this pathway, might prevent muscle breakdown and reduce stress in muscle cells.
Who could benefit from this research
Good fit: This research is relevant for patients living with chronic kidney disease who are experiencing or at risk of muscle weakness and loss.
Not a fit: Patients without chronic kidney disease or muscle wasting would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent or reverse muscle wasting, improving strength and quality of life for patients with chronic kidney disease.
How similar studies have performed: This approach explores a novel protein pathway, building on initial findings in mouse models and human cell cultures, rather than replicating previously successful human trials.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, ZHAOYONG — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: HU, ZHAOYONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.