Understanding and Treating Liver Disease (MASH) in Adults and Children
Official title: The Saint Louis University Component of the NASH Clinical Research Network
Funded at Saint Louis University · NIH-11169095 · Data updated 2026-11-12
This long-standing research effort aims to find better ways to diagnose, prevent, and treat a serious liver condition called MASH, which affects both adults and children.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 20, 2002 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,999 |
| NIH project number | 5U01DK061718-24 |
| Project ID | NIH-11169095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for related studies would be adults and children diagnosed with or at risk for metabolic dysfunction associated steatotic liver disease (MASLD) or metabolic dysfunction associated steatohepatitis (MASH).
✕Less likely to help
Patients without MASLD or MASH, or those with other forms of liver disease, may not directly benefit from this specific research.
What this research studies
This project is part of a large, ongoing research network focused on metabolic dysfunction associated steatotic liver disease (MASLD), especially its more severe form, MASH. Researchers are conducting clinical trials to test new treatments for MASH in both adults and children. They are also working to better understand how MASH develops and progresses, which can lead to improved diagnosis, prevention, and overall patient care. The goal is to reduce the significant health burden and costs associated with this common liver condition.
Why it matters
Potential benefit: If successful, this research could lead to new and more effective treatments, better diagnostic tools, and improved management strategies for MASH, potentially preventing serious liver damage and the need for liver transplants.
How similar studies have gone: The NASH Clinical Research Network has been active since 2002, indicating a sustained effort with ongoing clinical trials and translational research, suggesting a foundation of previous findings and progress.
Where this research is happening
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Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Neuschwander-Tetri, Brent a — Saint Louis University
- Study coordinator: Neuschwander-Tetri, Brent a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.