Understanding and treating Kaposiform Lymphangiomatosis
Pathogenesis and Treatment of Kaposiform Lymphangiomatosis
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11003320
This study is looking into Kaposiform lymphangiomatosis, a serious condition that affects kids under 11, to understand what causes it and how a medication called sirolimus might help improve treatment and care for these children.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11003320 on ClinicalTrials.gov |
What this research studies
This research focuses on Kaposiform lymphangiomatosis (KLA), a serious congenital condition affecting the lymphatic system, particularly in children under 11 years old. The study aims to explore the disease's underlying mechanisms, including the role of specific biomarkers like angiopoietin-2 and genetic mutations that may contribute to the condition. By investigating the effects of sirolimus, a medication that inhibits mTOR signaling, the research seeks to improve diagnosis and treatment options for KLA patients. The findings could lead to better management strategies and improved outcomes for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old diagnosed with Kaposiform lymphangiomatosis.
Not a fit: Patients with other types of lymphatic anomalies or those over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and treatment options for children suffering from Kaposiform lymphangiomatosis.
How similar studies have performed: Previous research has shown promise in using sirolimus for similar lymphatic conditions, indicating potential for success in this approach.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LE CRAS, TIMOTHY DAVID — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: LE CRAS, TIMOTHY DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.