Understanding and treating heart problems caused by cancer drugs
Novel mechanisms and therapeutics for Tyrosine Kinase Inhibitor-induced Cardiotoxicity
This study is looking at how a lung cancer medication called osimertinib might affect heart health, especially in causing heart problems, and aims to find ways to protect your heart while you’re being treated for cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11049672 on NIH RePORTER |
What this research studies
This research investigates how tyrosine kinase inhibitors (TKIs), particularly osimertinib used in lung cancer treatment, can lead to heart issues such as left ventricular dysfunction. The study aims to uncover the molecular mechanisms behind this cardiotoxicity and identify potential therapeutic targets to prevent or mitigate these heart problems. Using advanced techniques like single nucleus-RNA sequencing and human stem cell-derived heart cells, researchers will explore the effects of osimertinib on heart function. Patients may benefit from new strategies to protect their hearts while receiving cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients undergoing treatment with tyrosine kinase inhibitors, particularly those experiencing heart-related side effects.
Not a fit: Patients who are not receiving tyrosine kinase inhibitors or do not have heart issues related to cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect patients' hearts from damage caused by cancer treatments.
How similar studies have performed: Previous research has shown promising results in understanding and mitigating cardiotoxicity from cancer therapies, suggesting that this approach could lead to significant advancements.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Rhee, June-Wha — Beckman Research Institute/city of Hope
- Study coordinator: Rhee, June-Wha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.