Understanding and treating heart failure with preserved ejection fraction
Official title: Phenotype-specific models, mechanisms, and treatment of HFpEF
Funded at University of California at Davis · NIH-11124871 · Data updated 2026-11-12
This study is looking at heart failure with preserved ejection fraction (HFpEF) to find out more about the different types of this condition, especially in older adults and those with obesity, diabetes, or high blood pressure, so we can create better treatments that help improve their health and quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $539,408 |
| NIH project number | 5R01HL171057-02 |
| Project ID | NIH-11124871 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly women, who have been diagnosed with heart failure with preserved ejection fraction.
✕Less likely to help
Patients with heart failure with reduced ejection fraction or those without heart failure may not benefit from this research.
What this research studies
This research focuses on heart failure with preserved ejection fraction (HFpEF), a condition affecting millions of Americans, particularly the elderly and those with obesity, diabetes, and hypertension. The study aims to identify the different phenotypes of HFpEF to better understand the underlying mechanisms of the disease, which may differ significantly from other types of heart failure. By exploring these variations, the research seeks to develop targeted treatment options that could improve patient outcomes and quality of life. The approach includes analyzing patient data and biological markers to uncover the complexities of HFpEF.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for heart failure with preserved ejection fraction, significantly improving the quality of life for affected patients.
How similar studies have gone: While there has been significant research on heart failure, the specific focus on the phenotypic diversity of HFpEF and its treatment is relatively novel and has not been extensively tested.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Morotti, Stefano — University of California at Davis
- Study coordinator: Morotti, Stefano
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.