Understanding and Treating Fatty Liver Disease
Collaborative Clinical Research in Nonalcoholic Steatohepatitis
This opportunity is gathering information on fatty liver disease in adults and children and testing different doses of vitamin E for adults with this condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11166525 on NIH RePORTER |
What this research studies
We are continuing to collect important health information from adults and children who have nonalcoholic fatty liver disease (NAFLD) through an ongoing observational study. This helps us learn more about how the condition progresses over time. Additionally, we are completing a clinical trial that compares different doses of vitamin E to a placebo in adults with NAFLD and elevated liver enzymes. The goal is to see if vitamin E can help improve liver health in these patients.
Who could benefit from this research
Good fit: Ideal candidates include adults and children with biopsy-proven nonalcoholic fatty liver disease, and adults with NAFLD and elevated liver enzymes (ALT) who might participate in the vitamin E trial.
Not a fit: Patients without nonalcoholic fatty liver disease or those not meeting specific criteria for the vitamin E trial would not directly benefit from participation.
Why it matters
Potential benefit: If successful, this work could provide clearer guidance on vitamin E as a treatment for adults with fatty liver disease and improve our understanding of how NAFLD affects both children and adults.
How similar studies have performed: This work builds upon and completes ongoing studies and a clinical trial within an established network of clinical centers.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Chalasani, Naga P — Indiana University Indianapolis
- Study coordinator: Chalasani, Naga P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.