Understanding and treating diffuse axonal injury in traumatic brain injury
Official title: Molecular Mechanisms and Treatment of Diffuse Axonal Injury
Funded at University of Connecticut Sch of Med/dnt · NIH-10795102 · Data updated 2026-11-12
This study is looking into how brain injuries, like diffuse axonal injury, happen at a cellular level and aims to find new ways to treat them, which could help patients recover better in the future.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | October 18, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $218,864 |
| NIH project number | 5K08NS110929-05 |
| Project ID | NIH-10795102 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced traumatic brain injuries, particularly those with diffuse axonal injury.
✕Less likely to help
Patients with other types of brain injuries or those who do not have a history of traumatic brain injury may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind diffuse axonal injury (DAI), a common and severe type of traumatic brain injury. The principal investigator, with a strong background in neurobiology and neurosurgery, will explore how certain proteins and cellular responses contribute to DAI and develop potential treatment strategies. The approach includes advanced techniques in protein biochemistry, genomics, and neuroimaging to better understand the injury's effects and identify therapeutic targets. Patients may benefit from improved treatment options as a result of this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery outcomes for patients with traumatic brain injuries.
How similar studies have gone: Previous research has shown promise in understanding and treating traumatic brain injuries, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Kelley, Brian J. — University of Connecticut Sch of Med/dnt
- Study coordinator: Kelley, Brian J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.