Understanding and treating cognitive decline after a stroke
Progressive Post-Stroke Cognitive Impairment: Mechanisms & Intervention
['FUNDING_OTHER'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-11052672
This study is looking into how a stroke can affect thinking and memory, and it aims to find ways to help improve brain health and recovery for stroke survivors by understanding how blood vessel health impacts brain function.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-11052672 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind cognitive impairment that can occur after a stroke, known as post-stroke cognitive impairment (PSCI). It aims to explore how cerebrovascular health affects brain function and to identify potential therapeutic targets for treatment. By studying the endothelin system and its role in maintaining the integrity of blood vessels and neurons, the research seeks to develop strategies that could improve recovery and cognitive outcomes for stroke survivors. The approach includes using preclinical models to better understand the relationship between vascular health and cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a stroke and are showing signs of cognitive impairment.
Not a fit: Patients who have not had a stroke or do not exhibit cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or reduce cognitive decline in stroke survivors.
How similar studies have performed: Other research has shown promising results in understanding vascular contributions to cognitive impairment, suggesting that this approach may lead to significant advancements.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ERGUL, ADVIYE — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: ERGUL, ADVIYE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.