Understanding and treating back pain by targeting aging cells in spinal discs
Targeting cell senescence in a novel model of spontaneous disc degeneration
This work explores how aging cells in spinal discs contribute to chronic back and neck pain, using a new animal model to find better ways to help people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11086856 on NIH RePORTER |
What this research studies
Chronic neck and low back pain affect millions globally, often linked to spinal disc degeneration. We are developing a new animal model that naturally develops disc degeneration, similar to what happens in people, to better understand this common condition. Our goal is to uncover the genetic and cellular changes, especially those related to aging cells, that cause discs to break down. By understanding these root causes, we hope to find new ways to prevent or treat disc degeneration and the pain it causes.
Who could benefit from this research
Good fit: This foundational research does not involve human participants directly, but future clinical applications would target individuals experiencing chronic neck and low back pain due to disc degeneration.
Not a fit: Patients whose back or neck pain is not related to intervertebral disc degeneration or cellular aging may not benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target aging cells in spinal discs, potentially reducing chronic back and neck pain for many patients.
How similar studies have performed: While the concept of targeting senescent cells for various conditions is gaining traction, this specific animal model for spontaneous disc degeneration and its cellular mechanisms is novel.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Risbud, Makarand V — Thomas Jefferson University
- Study coordinator: Risbud, Makarand V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.