Understanding and treating auditory synapse degeneration
Regeneration of Auditory Synapses
['FUNDING_OTHER'] · JOHN D DINGELL VA MEDICAL CENTER · NIH-10876924
This study is looking into how certain connections in the ear that help us hear can break down, even when our hearing seems fine, and it hopes to find new ways to help people with hearing problems caused by things like brain injuries or getting older.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHN D DINGELL VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (DETROIT, UNITED STATES) |
| Trial ID | NIH-10876924 on ClinicalTrials.gov |
What this research studies
This research investigates the degeneration of auditory synapses, particularly focusing on the spiral ganglion neuron-cochlear nucleus synapse, which is crucial for transmitting auditory signals to the brain. It aims to uncover the molecular mechanisms behind this degeneration, which can occur even when hearing thresholds appear normal. By studying these mechanisms, the research seeks to develop new therapeutic approaches to address auditory processing deficits associated with conditions like traumatic brain injury and age-related hearing loss. Patients may benefit from insights that could lead to improved treatments for auditory dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with auditory processing issues, particularly those with a history of traumatic brain injury or age-related hearing loss.
Not a fit: Patients with purely conductive hearing loss or those without any auditory processing deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore auditory function and improve quality of life for individuals with auditory processing deficits.
How similar studies have performed: While the specific focus on central auditory synaptopathy is relatively novel, previous research has shown success in understanding and treating peripheral auditory synaptopathy.
Where this research is happening
DETROIT, UNITED STATES
- JOHN D DINGELL VA MEDICAL CENTER — DETROIT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, ZHENGQING — JOHN D DINGELL VA MEDICAL CENTER
- Study coordinator: HU, ZHENGQING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's disease transgenic mice