Understanding and treating atrial fibrillation using engineered heart tissue
Engineered Heart Tissue and Atrial Phenotyping Scientific Core 1
['FUNDING_P01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10896376
This study is looking at how genes and other factors affect atrial fibrillation, a heart rhythm issue, to find new ways to create safer and better treatments for people living with this condition.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10896376 on ClinicalTrials.gov |
What this research studies
This research focuses on atrial fibrillation, a common heart rhythm disorder that can worsen over time. It aims to explore the genetic and molecular mechanisms behind this condition, particularly how genes interact with metabolism and the environment. By using engineered heart tissue and induced pluripotent stem cells, the research seeks to identify new therapeutic targets that could lead to safer and more effective treatments for patients. The ultimate goal is to translate these findings into clinical applications that can improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for or diagnosed with atrial fibrillation, particularly those with contributing factors like obesity, hypertension, or diabetes.
Not a fit: Patients who do not have atrial fibrillation or related risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for atrial fibrillation, potentially reducing its progression and associated health burdens.
How similar studies have performed: Previous research has shown promise in using genetic and molecular approaches to understand and treat atrial fibrillation, indicating that this approach has potential for success.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAN WAGONER, DAVID R — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: VAN WAGONER, DAVID R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.