Understanding and Treating Aspirin-Exacerbated Respiratory Conditions
Official title: Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease
Funded at Brigham and Women's Hospital · NIH-11067831 · Data updated 2026-11-12
This research aims to understand why some people with asthma and nasal polyps react badly to aspirin, hoping to find better ways to help them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 15, 2011 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,535,611 |
| NIH project number | 5U19AI095219-15 |
| Project ID | NIH-11067831 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is relevant for individuals diagnosed with severe asthma, chronic rhinosinusitis with nasal polyps, and a history of aspirin sensitivity.
✕Less likely to help
Patients without aspirin-exacerbated respiratory disease or related severe asthma and nasal polyps may not directly benefit from this specific research.
What this research studies
We are exploring the underlying reasons why individuals with severe asthma and chronic nasal polyps experience worsened symptoms when exposed to aspirin. Our team is looking closely at specific cell changes and signals in the body, like those involving basal cells and mast cells, that contribute to this condition. We believe that interactions between these cells and certain immune pathways play a key role. This work combines laboratory studies with a small clinical trial to confirm our findings and see how they apply to patients.
Why it matters
Potential benefit: If successful, this research could lead to new and more effective treatments for people suffering from aspirin-exacerbated respiratory conditions.
How similar studies have gone: While the specific mechanisms being explored are novel, previous research has identified some of the cellular and molecular pathways involved in allergic and airway diseases.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Boyce, Joshua a — Brigham and Women's Hospital
- Study coordinator: Boyce, Joshua a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.