Understanding and Treating Arthritis Flares
Elucidating the Mechanisms of Arthritic Flare and Developing Treatments
This research aims to understand why rheumatoid arthritis flares happen and find better ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11143698 on NIH RePORTER |
What this research studies
Rheumatoid arthritis (RA) can cause painful joint inflammation and flares, even with current treatments. Our team uses advanced imaging and targeted therapies to look closely at how certain immune cells and lymphatic vessels in the body contribute to these flares. We are particularly interested in how changes in lymphatic flow and specific B cells might trigger a flare in people with RA. By understanding these processes, we hope to discover new ways to prevent or stop flares.
Who could benefit from this research
Good fit: This research is relevant for adult patients with rheumatoid arthritis who experience disease flares.
Not a fit: Patients without rheumatoid arthritis or those whose condition is well-controlled without flares may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that more effectively prevent or manage rheumatoid arthritis flares, improving quality of life for patients.
How similar studies have performed: Our team has conducted previous work in this area, developing a multidisciplinary approach that has shown promise in understanding flare mechanisms in both models and patients.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Schwarz, Edward M. — University of Rochester
- Study coordinator: Schwarz, Edward M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.