Understanding and treating aggressive prostate cancer
Official title: UCSF Specialized Programs of Research Excellence (SPOREs) in Prostate Cancer
Funded at University of California, San Francisco · NIH-10769613 · Data updated 2026-11-12
This study is looking into prostate cancer to find out what makes it aggressive and to develop better treatments, so men facing this disease can have more effective options and improved outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 2, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,204,158 |
| NIH project number | 1P50CA275741-01A1 |
| Project ID | NIH-10769613 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include men diagnosed with advanced or aggressive prostate cancer, particularly those with metastatic castration-resistant prostate cancer.
✕Less likely to help
Patients with early-stage prostate cancer or those without a diagnosis of prostate cancer may not benefit from this research.
What this research studies
This research focuses on prostate cancer, which is a leading cause of cancer deaths among men in the U.S. The UCSF Prostate Cancer SPORE aims to reduce the impact of this disease by exploring its biological mechanisms and developing new treatment strategies. The team will investigate the molecular drivers of aggressive prostate cancer, create biomarkers to guide treatment, and address therapeutic resistance in advanced cases. Through collaborative and transdisciplinary approaches, the research seeks to translate scientific findings into effective clinical applications.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with aggressive prostate cancer.
How similar studies have gone: Previous research has shown promise in similar approaches to understanding and treating prostate cancer, indicating potential for success in this area.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Small, Eric J — University of California, San Francisco
- Study coordinator: Small, Eric J
Related research
Other NIH-funded projects on the same topics.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
-
Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
A cancer research project looking at proteins linked to prostate cancer to better understand why it happens and how risk differs between African and European populations.
-
Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
A patient-friendly AI system uses ultrasound and MRI information to help doctors better find prostate cancer, aiming to improve accuracy and access.
-
Characterizing epigenetic targets in prostate cancer to help AR-driven cancer
A research project at MD Anderson aims to understand how epigenetic factors shape androgen receptor signaling in prostate cancer to find new ways to treat resistant forms of the disease.
-
AR and RNA-binding in prostate cancer resistance
A cancer research grant exploring how the androgen receptor’s interaction with RNA may drive treatment resistance in prostate cancer, with potential to guide new therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.