Understanding and tracking early psychosis risk
ProNET: Psychosis-Risk Outcomes Network
This project follows people at high risk for psychosis and healthy volunteers over two years to find brain, blood, speech, and digital signs that predict who will get worse.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11322379 on NIH RePORTER |
What this research studies
You would join one of 26 international sites where researchers follow people at high risk for psychosis and healthy volunteers over two years. They collect brain scans (MRI and EEG), blood and other body samples, genetics, natural speech recordings, and passively gathered digital information from phones, with most people seen 14 times over 24 months and biomarkers measured twice. The project plans about 1,040 high-risk participants and 390 healthy volunteers to map which patterns match different clinical courses. A smaller pilot will use advanced 7 Tesla MR spectroscopy to measure brain chemicals like glutamate and GABA.
Who could benefit from this research
Good fit: People identified as being at clinical high risk for psychosis—for example those with recent changes in thinking, perception, or functioning—are the main candidates, with healthy volunteers invited for comparison.
Not a fit: People already diagnosed with a full psychotic disorder or those unable to attend repeated in-person visits to participating sites are unlikely to gain direct benefit from this project.
Why it matters
Potential benefit: If successful, this could help doctors predict who is most likely to develop psychosis and tailor earlier treatments to prevent or reduce symptoms.
How similar studies have performed: Previous smaller clinical-high-risk studies have found some promising biomarkers but results have been inconsistent, so this larger multi-site effort seeks more reliable and generalizable signals.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Woods, Scott W — Yale University
- Study coordinator: Woods, Scott W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.