Understanding and targeting the molecular drivers of glioblastoma
Oncogenic mechanisms, molecular stratification and therapeutic targets of brain tumors
['FUNDING_OTHER'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-11172467
This project uses advanced lab models and computer analyses to find tumor subgroups and new treatment targets for people with glioblastoma.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-11172467 on ClinicalTrials.gov |
What this research studies
From a patient's perspective, the team combines computer tools with lab models and tumor samples to group glioblastoma tumors that behave the same way. They profile individual tumor cells using high-throughput RNA and protein methods to see which pathways are active in each cell. The researchers aim to find the key tumor 'drivers' and pairs of vulnerabilities that can be targeted with drugs. Some leads from this group have already moved into clinical testing, and the work is tied to a wider clinical network.
Who could benefit from this research
Good fit: Ideal candidates would be people diagnosed with glioblastoma who can provide tumor tissue and are willing to take part in molecular profiling or trials at the study sites.
Not a fit: People without glioblastoma, those unwilling or unable to provide tumor samples, or those not eligible for related clinical trials are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could lead to more precise, personalized therapies and new drug targets for people with glioblastoma.
How similar studies have performed: Related efforts using tumor subgrouping and single-cell profiling have identified actionable targets in some cancers, and findings from this lab have already progressed into clinical studies.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IAVARONE, ANTONIO — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: IAVARONE, ANTONIO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Genes, Cancer Model, Cancer Patient, Cancer-Promoting Gene, CancerModel