Understanding and targeting the immune environment in lymphoma
Official title: Epigenetic basis and therapeutic targeting of the unique lymphoma immunological niche
Funded at Weill Medical Coll of Cornell Univ · NIH-10847986 · Data updated 2026-11-12
This study is looking at how certain genetic changes in diffuse large B-cell lymphoma (DLBCL) affect the cancer's relationship with the immune system, with the goal of finding better treatments for patients like you.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 12, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,561,215 |
| NIH project number | 1P01CA272295-01A1 |
| Project ID | NIH-10847986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with diffuse large B-cell lymphoma, particularly those with varying responses to current therapies.
✕Less likely to help
Patients with other types of lymphoma or those who do not have B-cell malignancies may not benefit from this research.
What this research studies
This research investigates diffuse large B-cell lymphoma (DLBCL), a type of aggressive cancer that arises from B-cells. It focuses on the genetic mutations that affect how these cancer cells interact with their surrounding immune environment. By examining the mechanisms behind these mutations and their impact on the lymphoma microenvironment, the research aims to develop targeted therapies that can improve treatment outcomes. The team utilizes advanced technologies and models to explore these complex interactions and their implications for patient care.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients with diffuse large B-cell lymphoma.
How similar studies have gone: Previous research has shown promise in targeting the immune environment in various cancers, suggesting that this approach could yield significant advancements in lymphoma treatment.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Cerchietti, Leandro C — Weill Medical Coll of Cornell Univ
- Study coordinator: Cerchietti, Leandro C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.