Understanding and targeting pain and progression in knee osteoarthritis
Official title: BCCMA: Targeting Osteoarthritis Pain and Progression: Defining biologic and inflammatory markers associated with rapid progression
Funded at Veterans Admin Palo Alto Health Care Sys · NIH-11044086 · Data updated 2026-11-12
This study is looking at how certain biological markers relate to knee pain and the worsening of osteoarthritis, especially in younger veterans, to help find better treatments that can ease pain and slow down joint damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Admin Palo Alto Health Care Sys NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01CX002527-03 |
| Project ID | NIH-11044086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans experiencing knee osteoarthritis symptoms without significant radiographic signs of the disease.
✕Less likely to help
Patients with advanced knee osteoarthritis showing significant radiographic changes may not benefit from this research.
What this research studies
This research investigates the biological and inflammatory markers associated with knee osteoarthritis (OA) pain and progression, particularly in veterans who experience OA at younger ages. The study aims to identify the immune responses that contribute to the variability in OA symptoms and structural changes in the joints. By analyzing both clinical data from patients and animal models, the research seeks to develop targeted treatments that can alleviate pain and slow down the progression of OA before significant joint damage occurs.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce pain and prevent the progression of knee osteoarthritis.
How similar studies have gone: Previous research has shown promise in targeting immune responses in osteoarthritis, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
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Veterans Admin Palo Alto Health Care Sys
Palo Alto, United States Active
Researchers
- Principal investigator: Chu, Constance R — Veterans Admin Palo Alto Health Care Sys
- Study coordinator: Chu, Constance R
Related research
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-
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Nanoparticles delivering an sPLA2 blocker for knee osteoarthritis
This project uses tiny, drug-filled nanoparticles to deliver an sPLA2-blocking medicine into the knee to reduce inflammation and slow knee osteoarthritis in people with painful knee OA.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.