Understanding and targeting pain and progression in knee osteoarthritis
BCCMA: Targeting Osteoarthritis Pain and Progression: Defining biologic and inflammatory markers associated with rapid progression
['FUNDING_OTHER'] · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · NIH-11044086
This study is looking at how certain biological markers relate to knee pain and the worsening of osteoarthritis, especially in younger veterans, to help find better treatments that can ease pain and slow down joint damage.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS ADMIN PALO ALTO HEALTH CARE SYS (nih funded) |
| Locations | 1 site (PALO ALTO, UNITED STATES) |
| Trial ID | NIH-11044086 on ClinicalTrials.gov |
What this research studies
This research investigates the biological and inflammatory markers associated with knee osteoarthritis (OA) pain and progression, particularly in veterans who experience OA at younger ages. The study aims to identify the immune responses that contribute to the variability in OA symptoms and structural changes in the joints. By analyzing both clinical data from patients and animal models, the research seeks to develop targeted treatments that can alleviate pain and slow down the progression of OA before significant joint damage occurs.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans experiencing knee osteoarthritis symptoms without significant radiographic signs of the disease.
Not a fit: Patients with advanced knee osteoarthritis showing significant radiographic changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce pain and prevent the progression of knee osteoarthritis.
How similar studies have performed: Previous research has shown promise in targeting immune responses in osteoarthritis, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
PALO ALTO, UNITED STATES
- VETERANS ADMIN PALO ALTO HEALTH CARE SYS — PALO ALTO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHU, CONSTANCE R — VETERANS ADMIN PALO ALTO HEALTH CARE SYS
- Study coordinator: CHU, CONSTANCE R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.