Understanding and targeting mutations in histone proteins related to bladder cancer
Elucidating and targeting the effects of oncogenic histone mutations
['FUNDING_CAREER'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10706345
This study is looking at how certain changes in proteins called histones might lead to bladder cancer, and it's trying to find new ways to treat patients with these changes by understanding how they affect cells.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10706345 on ClinicalTrials.gov |
What this research studies
This research investigates how specific mutations in histone proteins contribute to bladder cancer development. By examining the effects of these mutations on chromatin structure and gene expression, the researchers aim to identify potential therapeutic strategies to target tumors with these mutations. The study involves laboratory experiments that analyze the impact of these mutations on cellular behavior and differentiation, with the goal of developing new treatment options for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with bladder cancer who have mutations in histone proteins.
Not a fit: Patients without bladder cancer or those whose tumors do not harbor histone mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for bladder cancer patients with specific histone mutations.
How similar studies have performed: Other research has shown promising results in targeting oncogenic mutations in cancer, suggesting that this approach could be effective.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NACEV, BENJAMIN A — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: NACEV, BENJAMIN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bladder Cancer, Urinary Bladder Cancer, Cancers