Understanding and targeting lung cancer differences in African American men
Discovery and therapeutic targeting of biological determinants of lung cancer health disparities
This study is looking into why lung cancer affects African American men more severely than European American men, focusing on specific changes in their cells that might make the cancer worse, with the goal of finding better treatments to help those who are diagnosed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11017693 on NIH RePORTER |
What this research studies
This research investigates the biological factors that contribute to the higher incidence and poorer survival rates of lung cancer among African American men compared to European American men. It focuses on the JAK/STAT3 signaling pathway, which may be more frequently mutated in lung adenocarcinoma (a common type of lung cancer) in African Americans. By identifying these mutations and their effects on cancer progression and treatment resistance, the research aims to develop targeted therapies that could improve outcomes for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American men diagnosed with non-small cell lung cancer, particularly lung adenocarcinoma.
Not a fit: Patients who do not identify as African American or those with other types of lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments specifically tailored for African American men with lung cancer.
How similar studies have performed: Previous research has shown promising results in targeting specific biological pathways in cancer treatment, suggesting potential for success in this approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Pine, Sharon R. — University of Colorado Denver
- Study coordinator: Pine, Sharon R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.