Understanding and targeting early stem cells involved in leukemia
Molecular and Cellular Regulation of Pre-Leukemic Stem Cells and their Therapeutic Targeting
This study is looking at the early changes in blood cells that can lead to acute myeloid leukemia (AML) to find new ways to treat it, so patients with AML might have better treatment options in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10898663 on NIH RePORTER |
What this research studies
This research investigates the early stages of leukemia development, focusing on pre-leukemic stem cells that can lead to acute myeloid leukemia (AML). By examining the molecular and cellular mechanisms that regulate these stem cells, the research aims to uncover new therapeutic targets. The approach involves studying the genetic and transcriptional factors that influence the behavior of these cells, which could lead to more effective treatments for patients with AML. Patients may benefit from insights that could improve treatment strategies and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 55 years of age, who are at risk for or diagnosed with acute myeloid leukemia.
Not a fit: Patients with other types of leukemia or those who are younger than 55 years may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with acute myeloid leukemia, potentially improving survival rates.
How similar studies have performed: Other research has shown promising results in targeting early stem cells in leukemia, indicating that this approach has potential for success.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Steidl, Ulrich — Albert Einstein College of Medicine
- Study coordinator: Steidl, Ulrich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.