Understanding and targeting communication pathways in pancreatic cancer
Elucidation and targeting of paracrine cascades in PDAC
['FUNDING_U01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10914226
This study is looking at how the tissue around pancreatic cancer affects treatment, with the goal of finding better ways to deliver drugs and improve outcomes for patients battling this tough disease.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10914226 on ClinicalTrials.gov |
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDAC), a highly lethal cancer that often resists current treatments. It investigates the complex interactions within the tumor's surrounding tissue, known as the stroma, which can hinder the effectiveness of therapies. By exploring how different signaling pathways work together, the research aims to identify new ways to enhance drug delivery and improve treatment outcomes for patients. The approach includes analyzing the tumor microenvironment and its impact on therapy response.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma who are seeking new treatment options.
Not a fit: Patients with other types of cancer or those who do not have pancreatic ductal adenocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pancreatic cancer, improving survival rates and quality of life for patients.
How similar studies have performed: While there have been attempts to target the tumor stroma in pancreatic cancer, this research proposes a novel approach by reconstructing paracrine cascades, which has not been extensively tested in this context.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OLIVE, KENNETH P. — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: OLIVE, KENNETH P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.