Understanding and targeting chromosome abnormalities in cancer
Deconstructing and targeting aneuploidy in human cancer - Resubmission - 1
['FUNDING_R37'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11059186
This study is looking at how having the wrong number of chromosomes in cells can affect the growth and treatment of tumors, and it's for anyone interested in finding better ways to treat cancer by understanding these chromosome changes.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11059186 on ClinicalTrials.gov |
What this research studies
This research investigates how aneuploidy, which is the presence of an abnormal number of chromosomes, contributes to the development and progression of human tumors. The researchers aim to create cellular models that mimic the aneuploidy patterns found in actual tumors, allowing them to study how these abnormalities affect tumor cell behavior, including growth and resistance to treatment. By identifying vulnerabilities linked to aneuploidy, the research seeks to develop new therapeutic strategies that could improve cancer treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients whose tumors exhibit aneuploidy, particularly those with solid tumors.
Not a fit: Patients with cancers that do not exhibit aneuploidy or those with early-stage cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer therapies that specifically target the vulnerabilities associated with aneuploidy in tumors.
How similar studies have performed: While there has been some research on aneuploidy in cancer, this approach of creating specific cellular models to study its effects is relatively novel and has not been extensively tested.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVOLI, TERESA — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: DAVOLI, TERESA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, cancer cell, Cancer cell line, Cancer Patient, cancer progression