Understanding and targeting a new pathway in liver cancer
Deciphering and targeting a non-genetic driver pathway in hepatocellular carcinoma
['FUNDING_R01'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11010818
This study is looking at a protein called BCL6 to see how it helps liver cancer grow, and it's trying to find new treatments that could help people with this type of cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11010818 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called BCL6 in the development of hepatocellular carcinoma (HCC), a common type of liver cancer. By using advanced techniques, the researchers aim to understand how BCL6 contributes to tumor growth and explore new small-molecule inhibitors that could target this protein. The study involves both laboratory experiments and mouse models to mimic the disease, providing insights that could lead to innovative therapies for patients with HCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hepatocellular carcinoma or those at high risk for developing this type of liver cancer.
Not a fit: Patients with other types of cancer or those without liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for liver cancer, improving treatment options and outcomes for patients.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in cancer treatment, suggesting that this approach could be effective.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WAJAPEYEE, NARENDRA — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: WAJAPEYEE, NARENDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: American Cancer Society