Understanding and stopping antibiotic resistance caused by specific enzymes
Evolution and inhibition of carbapenemase in beta-lactam resistance
This study is looking at how certain enzymes make bacteria resistant to important antibiotics, and it's working on creating new medicines that can stop these enzymes so that patients can have better treatment options for tough infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11051272 on NIH RePORTER |
What this research studies
This research investigates how certain enzymes, known as carbapenemases, contribute to antibiotic resistance, particularly against a class of antibiotics called carbapenems. The team is using advanced drug discovery techniques to develop new inhibitors that can effectively target these enzymes, which are becoming increasingly resistant to existing treatments. By analyzing the structure of these enzymes and their interactions with potential inhibitors, the research aims to find effective solutions to combat infections caused by resistant bacteria. Patients may benefit from new treatments that can overcome these resistant infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by carbapenem-resistant bacteria, particularly those with serious or life-threatening conditions.
Not a fit: Patients with infections caused by bacteria that are not resistant to carbapenems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat infections caused by resistant bacteria.
How similar studies have performed: Other research has shown promise in developing inhibitors for similar antibiotic resistance mechanisms, indicating a potential for success in this area.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Chen, Yu — University of South Florida
- Study coordinator: Chen, Yu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.