Understanding and reversing eye membrane contractions in retinal diseases
Reversing Contractility in Epiretinal Membranes
This study is looking at how certain eye conditions, like PVR and PDR, cause the formation of membranes in the eye, and it aims to find new ways to treat these issues by understanding the genes involved in this process, so we can help improve vision for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10828762 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the formation of epiretinal membranes in patients suffering from retinal diseases like Proliferative Vitreoretinopathy (PVR) and Proliferative Diabetic Retinopathy (PDR). By analyzing the genetic components involved in the contraction of these membranes, the researchers aim to identify potential treatment targets that could prevent or reverse the contraction process. The study employs advanced techniques such as whole transcriptome sequencing to uncover contraction-associated genes and their roles in membrane behavior. Ultimately, the goal is to develop effective therapies that can improve patient outcomes by addressing the underlying causes of these eye disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Proliferative Vitreoretinopathy or Proliferative Diabetic Retinopathy.
Not a fit: Patients with other types of retinal diseases not related to membrane contraction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse vision loss caused by retinal membrane contractions.
How similar studies have performed: Previous research has shown promise in understanding the genetic factors involved in retinal diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Blenkinsop, Timothy a. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Blenkinsop, Timothy a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.