Understanding and reversing abnormal brain activity in Alzheimer's Disease
Official title: Identifying the mechanistic role of and reversing aberrant neural activity in Alzheimer's Disease
Funded at Stanford University · NIH-10896399 · Data updated 2026-11-12
This study is looking at how unusual brain activity affects Alzheimer's Disease and is trying to find ways to fix it, so it’s for anyone interested in understanding more about the disease and how we might be able to detect and treat it earlier.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $128,331 |
| NIH project number | 5K99AG080110-02 |
| Project ID | NIH-10896399 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's Disease or those in the early stages of cognitive decline.
✕Less likely to help
Patients with advanced Alzheimer's Disease or those with other forms of dementia may not benefit from this research.
What this research studies
This research investigates how abnormal neural activity contributes to Alzheimer's Disease and explores potential therapeutic approaches to reverse this activity. By using advanced techniques like 2-photon imaging, the study aims to identify specific patterns of neural dysfunction that may lead to cognitive decline. The research focuses on understanding the relationship between amyloid-beta and tau proteins and their impact on brain activity, which could provide insights into earlier detection and treatment of the disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve cognitive function in patients with Alzheimer's Disease.
How similar studies have gone: Other research has shown promise in targeting neural activity to improve cognitive outcomes, suggesting that this approach could be effective.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Ho, Theodore Terence — Stanford University
- Study coordinator: Ho, Theodore Terence
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.