Understanding and repairing kidney damage from cold storage before transplant
Mechanisms and Ex Vivo Repair of Cold-Storage Injury in Human Kidney Allografts
This study is looking at how keeping kidneys in cold storage affects their health before a transplant, especially for kidneys from older donors or those with health problems, and it aims to find better ways to protect these kidneys so they work well after being transplanted.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10771973 on NIH RePORTER |
What this research studies
This research investigates how cold storage affects human kidney transplants, particularly focusing on the injuries that occur during this process. It aims to understand the mechanisms behind these injuries, especially in kidneys from aging donors or those with health issues. By studying the production of fibrinogen in kidney cells during cold storage, the researchers hope to find ways to improve kidney resilience and reduce complications after transplantation. The approach involves using Ex Vivo Organ Perfusion (EVOP) to test potential therapeutic strategies in a controlled environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals awaiting kidney transplants, particularly those receiving organs from older donors or donors with co-morbidities.
Not a fit: Patients who are not candidates for kidney transplantation or those receiving organs from healthy, younger donors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for kidney transplant patients by reducing post-transplant complications.
How similar studies have performed: Other research has shown promise in understanding cold storage injuries in organ transplants, but this specific approach targeting fibrinogen is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Pober, Jordan S — Yale University
- Study coordinator: Pober, Jordan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.