Understanding and redirecting cellular redox signals
Decoding and Reprogramming Redox Signal Transduction Pathways
['FUNDING_OTHER'] · UNIVERSITY OF MINNESOTA · NIH-11260848
Researchers are working to understand how cells use reactive molecules to send signals and to design ways to correct those signals in conditions like Alzheimer's and cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11260848 on ClinicalTrials.gov |
What this research studies
From your perspective, this lab is studying how cells sense and respond to reactive molecules such as nitric oxide, carbon monoxide, and reactive oxygen species. The team examines the enzymes and pathways that make these redox signals specific and reliable, even though the chemicals involved are highly reactive. They aim to develop molecular strategies that can reprogram those sensing and signaling mechanisms to restore or alter cellular redox balance. Most of the work is done in the lab using biochemical and molecular tools rather than enrolling patients.
Who could benefit from this research
Good fit: This project is primarily laboratory-based and does not currently enroll patients, though future trials would likely focus on people with Alzheimer's disease or cancers linked to redox imbalance.
Not a fit: Patients seeking immediate clinical treatments or those whose conditions are not related to redox imbalance are unlikely to gain direct benefit from this basic research in the near term.
Why it matters
Potential benefit: If successful, this work could lead to new therapies that restore healthy redox signaling and slow or prevent damage in diseases like Alzheimer's and some cancers.
How similar studies have performed: Related efforts targeting oxidative stress have had mixed clinical results, so this approach of reprogramming redox signaling is relatively new and more experimental.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BHAGI, AMBIKA — UNIVERSITY OF MINNESOTA
- Study coordinator: BHAGI, AMBIKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Cancers