Understanding and preventing youth-onset type 2 diabetes
Official title: The PRIORITY Study: from PRedIctiOn to pReventIon of youth-onset TYpe 2 diabetes
Funded at Johns Hopkins University · NIH-11052515 · Data updated 2026-11-12
This study is looking at what causes type 2 diabetes in young people, especially those who might be more at risk, to help find better ways to predict who could develop the condition and how social factors play a role, all while working with trusted doctors to include kids from different backgrounds.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 22, 2023 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $681,677 |
| NIH project number | 5U01DK134975-03 |
| Project ID | NIH-11052515 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adolescents aged 10 to 21 who are at risk for developing youth-onset type 2 diabetes, particularly those from racial and ethnic minority backgrounds.
✕Less likely to help
Patients who are not adolescents or those who do not have risk factors for youth-onset type 2 diabetes may not benefit from this research.
What this research studies
This research focuses on identifying the risk factors and mechanisms that lead to youth-onset type 2 diabetes (YoT2D) in adolescents, particularly those from vulnerable populations. By studying early pubertal youth at risk for YoT2D, the research aims to develop better prediction methods for who may progress from prediabetes to diabetes. The study will also explore how social determinants of health impact these outcomes, utilizing trusted pediatric care providers to recruit participants from diverse backgrounds. This comprehensive approach seeks to address the urgent need for effective prevention strategies in at-risk youth.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for youth-onset type 2 diabetes, ultimately reducing its prevalence and associated health complications.
How similar studies have gone: Previous research has shown success in understanding diabetes risk factors in youth, but this study aims to innovate by focusing on social determinants and specific vulnerable populations.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Magge, Sheela Natesh — Johns Hopkins University
- Study coordinator: Magge, Sheela Natesh
Related research
Other NIH-funded projects on the same topics.
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Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
-
Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes
A peer-led self-management program for adults with type 2 diabetes is being tested to see if it improves blood sugar control and daily diabetes care.
-
Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.
-
Personalized use of newer diabetes medicines for Type 2 diabetes
Aiming to tailor use of newer glucose-lowering drugs for people with type 2 diabetes to improve health and access in real-world settings.
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Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes
This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
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Understanding why youth develop type 2 diabetes and how to prevent it
A nationwide study aims to unravel why some teens with obesity develop type 2 diabetes while others don’t, and to identify factors that could help prevent it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.