Understanding and preventing memory issues after surgery in older adults
Postoperative Neurocognitive Disorder - Strategies for Prevention or Reversal Based on Molecular ad Cellular Mechanisms
This study is looking at how getting older can impact memory and thinking skills after surgery, especially for older adults, and it aims to find ways to help improve or protect these skills during recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-11073089 on NIH RePORTER |
What this research studies
This research investigates how aging affects cognitive function after surgery, particularly focusing on postoperative neurocognitive disorder (poNCD). It aims to explore the molecular and cellular mechanisms that contribute to memory decline in older adults undergoing anesthesia. By studying the role of specific receptors in the brain, the research seeks to identify strategies that could prevent or reverse cognitive impairments associated with surgery. The approach includes testing various compounds that may enhance cognitive function and mitigate memory loss.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 60 and above who are scheduled for surgical procedures requiring anesthesia.
Not a fit: Patients under the age of 60 or those not undergoing surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective strategies for preventing memory problems in older adults after surgery.
How similar studies have performed: Previous research has shown promising results in animal models regarding the modulation of specific receptors to improve cognitive outcomes after anesthesia, suggesting potential for success in this area.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Rudolph, Uwe — University of Illinois at Urbana-Champaign
- Study coordinator: Rudolph, Uwe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.