Understanding and preventing gastric cancer caused by Helicobacter pylori infection
Official title: Precision Interception of Gastric Cancer Precursors Through Molecular and Cellular Risk Stratification
Funded at Stanford University · NIH-10932166 · Data updated 2026-11-12
This study is looking at how a common stomach bacteria might lead to stomach cancer, and it's for people who have precancerous changes in their stomach, helping to find out who might be at greater risk so we can catch problems early and prevent cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,715,269 |
| NIH project number | 5P01CA265772-02 |
| Project ID | NIH-10932166 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals infected with Helicobacter pylori who have been diagnosed with gastric intestinal metaplasia or are at risk for developing gastric cancer.
✕Less likely to help
Patients who do not have Helicobacter pylori infection or those without any precancerous lesions may not benefit from this research.
What this research studies
This research investigates how the bacterium Helicobacter pylori contributes to the development of gastric cancer by examining the molecular and cellular characteristics of precancerous lesions. It aims to identify which patients are at higher risk for developing invasive cancer based on their unique biological markers and the nature of their gastric environment. The study employs advanced techniques such as single-cell sequencing to analyze gastric epithelial cells and create models that simulate precancerous conditions. By stratifying patients based on their risk factors, the research seeks to improve early detection and prevention strategies for gastric cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective screening and prevention strategies for gastric cancer, potentially saving lives.
How similar studies have gone: Previous research has shown promising results in understanding the role of Helicobacter pylori in gastric cancer, indicating that this approach could build on established findings.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Ji, Hanlee P — Stanford University
- Study coordinator: Ji, Hanlee P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.