Understanding and preventing complications in childhood stroke
Childhood arterial ischemic stroke: role of TLR4-neutrophil axis in injury and hemorrhagic transformation
This research explores how the body's immune response contributes to injury and bleeding after a stroke in children, aiming to find new ways to protect their brains.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11050412 on NIH RePORTER |
What this research studies
When blood flow returns to the brain after a stroke, it can sometimes cause more harm, especially if delayed. While treatments like mechanical thrombectomy help adults, we don't fully understand the risks and benefits for children with arterial ischemic stroke. This project uses advanced mouse models of childhood stroke to learn more about why delayed blood flow restoration can lead to bleeding and further brain damage. We are focusing on a specific immune pathway involving TLR4 and neutrophils to uncover the mechanisms behind these complications. Our goal is to identify new medicines that could reduce injury and prevent bleeding in children after a stroke.
Who could benefit from this research
Good fit: This foundational research focuses on understanding childhood arterial ischemic stroke, which could eventually benefit children aged 0-11 who experience this condition.
Not a fit: Patients without childhood arterial ischemic stroke or those outside the age range of focus for this condition may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that protect children from brain injury and bleeding complications after a stroke, improving their long-term outcomes.
How similar studies have performed: Knowledge about the specific mechanisms of adverse effects from late blood flow restoration in childhood stroke is currently very limited, making this a novel and important area of exploration.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Vexler, Zinaida S — University of California, San Francisco
- Study coordinator: Vexler, Zinaida S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.