Understanding and predicting cancer-related fatigue during chemotherapy
Official title: An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach
Funded at University of California, San Francisco · NIH-10789801 · Data updated 2026-11-12
This study is looking into why some cancer patients feel really tired during treatment and aims to create a tool that helps doctors spot those who might struggle the most with fatigue, so they can offer personalized tips to help manage it and improve their overall well-being.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 3, 2019 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $624,441 |
| NIH project number | 4R37CA233774-06 |
| Project ID | NIH-10789801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients currently receiving chemotherapy or radiation therapy who are experiencing or at risk of severe fatigue.
✕Less likely to help
Patients who are not undergoing chemotherapy or radiation therapy may not benefit from this research.
What this research studies
This research investigates the causes and severity of cancer-related fatigue (CRF), a common and debilitating symptom experienced by cancer patients undergoing treatment. By utilizing a multi-staged integrated omics approach, the study aims to develop a risk prediction model that can identify patients at high risk for severe CRF. This model will help clinicians provide tailored recommendations for managing fatigue, such as exercise interventions, and improve overall patient quality of life. The research also seeks to uncover the biological mechanisms behind CRF, potentially leading to new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for cancer-related fatigue, enhancing the quality of life for patients undergoing chemotherapy.
How similar studies have gone: Previous research has indicated that understanding the mechanisms of cancer-related fatigue can lead to improved management strategies, suggesting that this approach has potential for success.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Kober, Kord Michael — University of California, San Francisco
- Study coordinator: Kober, Kord Michael
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This study is looking at how changes in energy production in your cells might be causing fatigue for breast cancer patients like you who are undergoing chemotherapy with anthracycline drugs, and it aims to find ways to help manage that tiredness better.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.