Understanding and predicting Alzheimer's disease through DNA changes related to aging
New computational tools for understanding and predicting AD via age-associated DNA methylation changes
This study is looking at how changes in our DNA as we age might help us understand and predict Alzheimer's disease, and it aims to create easy-to-use tools for doctors to help them diagnose and manage the condition, while also considering how our lifestyle choices might affect these DNA changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10509428 on NIH RePORTER |
What this research studies
This research focuses on Alzheimer's disease (AD), particularly how age-related changes in DNA methylation can serve as biomarkers for the disease. By analyzing large datasets of DNA methylation, the researchers aim to identify patterns that could help in diagnosing and predicting AD. They will develop user-friendly tools and a web interface to share their findings, making it easier for healthcare providers to access this information. The study also explores how lifestyle factors may influence these DNA changes and the risk of developing AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 65, who may be at risk for Alzheimer's disease.
Not a fit: Patients with early-onset Alzheimer's disease or those under 65 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and accessible methods for diagnosing and predicting Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in using DNA methylation as biomarkers for various diseases, suggesting that this approach could be effective for Alzheimer's disease as well.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Wang, Lily — University of Miami School of Medicine
- Study coordinator: Wang, Lily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.