Understanding and overcoming resistance to cisplatin in head and neck cancer
The Houston Center for Acquired Resistance Research (H-CARR)
This study is looking at why some head and neck cancers don’t respond well to a common treatment called cisplatin, with the goal of finding better ways to detect and overcome this resistance, so patients can have more effective treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11010062 on NIH RePORTER |
What this research studies
This research focuses on head and neck squamous cell carcinoma (HNSCC), a major cause of cancer-related deaths. It aims to uncover the biological mechanisms behind cisplatin resistance, a common challenge in treatment. By studying how cancer cells process cisplatin and the metabolic stress they experience, the research seeks to develop methods for early detection of resistance and strategies to overcome it. The project utilizes advanced imaging techniques and analysis of circulating tumor cells to gain insights into the cancer's response to treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with head and neck squamous cell carcinoma who are undergoing treatment with cisplatin.
Not a fit: Patients with head and neck cancers that are not treated with cisplatin or those with other types of cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with cisplatin-resistant head and neck cancer.
How similar studies have performed: Previous research has shown promise in understanding cancer resistance mechanisms, indicating potential for success in this novel approach.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Myers, Jeffrey Nicholas — University of Tx Md Anderson Can Ctr
- Study coordinator: Myers, Jeffrey Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.