Understanding and overcoming resistance to cisplatin in head and neck cancer
The Houston Center for Acquired Resistance Research (H-CARR)
This study is looking at why some people with head and neck cancer don’t respond well to the common treatment cisplatin, and it aims to find ways to spot this resistance early and improve treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10917404 on NIH RePORTER |
What this research studies
This research focuses on head and neck squamous cell carcinoma (HNSCC), a major cause of cancer deaths, particularly examining why some patients develop resistance to cisplatin, the standard treatment. The team aims to identify biological markers and metabolic changes that contribute to this resistance, using advanced techniques to analyze tumor metabolism and circulating tumor cells. By understanding these mechanisms, the research seeks to develop methods for early detection of resistance and strategies to overcome it, potentially improving treatment outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with head and neck squamous cell carcinoma who are undergoing treatment with cisplatin.
Not a fit: Patients with head and neck cancers that are not treated with cisplatin or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with cisplatin-resistant head and neck cancer.
How similar studies have performed: Previous research has shown promise in understanding cisplatin resistance, but this approach aims to provide a more comprehensive and novel perspective on the issue.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Myers, Jeffrey Nicholas — University of Tx Md Anderson Can Ctr
- Study coordinator: Myers, Jeffrey Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.