Understanding and overcoming resistance in KRAS-driven cancers
Targeting Acquired Resistance in KRAS Driven Cancers
This study is looking at why some cancers with a KRAS mutation don't respond to new treatments and aims to find better ways to help patients by understanding how these tumors resist therapy.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10895586 on NIH RePORTER |
What this research studies
This research focuses on the challenges posed by treatment resistance in cancers driven by the KRAS mutation, which is common in various cancer types. The team will investigate how tumors develop resistance to newly approved KRAS inhibitors, using advanced laboratory models that mimic human cancer. By studying both cell cultures and patient-derived cancer models, the research aims to uncover the mechanisms behind this resistance and identify new treatment strategies that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with KRAS-driven cancers, such as pancreatic or colorectal cancer, who may benefit from targeted therapies.
Not a fit: Patients without KRAS mutations or those with cancers not driven by KRAS may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with KRAS-mutated cancers, potentially overcoming current limitations in therapy.
How similar studies have performed: Previous research has shown promise in targeting KRAS mutations, but this specific approach to understanding and overcoming resistance is novel and untested.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Yao, Wantong — University of Tx Md Anderson Can Ctr
- Study coordinator: Yao, Wantong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.