Understanding and Modifying Proteins for Health
Official title: Developing synthetic chemical biology strategies for biochemical investigations and biomedical applications
Funded at University of Nebraska Lincoln · NIH-11133040 · Data updated 2026-11-12
This work explores new ways to understand and change proteins in our bodies, which are key to many biological processes and diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $370,327 |
| NIH project number | 5R35GM149322-03 |
| Project ID | NIH-11133040 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational laboratory work does not directly involve patients, but future applications could benefit individuals with diseases linked to protein function.
✕Less likely to help
Patients seeking immediate clinical treatments or direct participation in a human study would not find direct benefit from this basic science project.
What this research studies
Our bodies rely on proteins for almost everything, and changes to these proteins can lead to illness. This project looks at both natural protein changes and new ways to modify proteins using advanced genetic tools. We are working to reprogram the genetic code to better control how proteins are made and changed. This approach could help us discover innovative strategies for manipulating protein function.
Why it matters
Potential benefit: If successful, this fundamental work could lead to the development of new medicines and treatments for various diseases.
How similar studies have gone: This project builds on pioneering efforts in genetic code engineering and explores new directions to improve protein modification techniques.
Where this research is happening
-
University of Nebraska Lincoln
Lincoln, United States Active
Researchers
- Principal investigator: Guo, Jiantao — University of Nebraska Lincoln
- Study coordinator: Guo, Jiantao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.