Understanding and managing bone and mineral disorders in chronic kidney disease
Official title: Systems Biology Approach to the Management of Chronic Kidney Disease-Mineral Bone Disorder
Funded at VA North Texas Health Care System · NIH-11043305 · Data updated 2026-11-12
This study is looking at how chronic kidney disease affects important minerals in your body, like phosphate and calcium, and aims to find better ways to treat these issues by using advanced technology to personalize care just for you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA North Texas Health Care System NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | October 1, 2018 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01CX001614-06 |
| Project ID | NIH-11043305 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans suffering from chronic kidney disease who are experiencing complications related to mineral metabolism.
✕Less likely to help
Patients with chronic kidney disease who do not have significant mineral metabolism issues may not benefit from this research.
What this research studies
This research investigates how chronic kidney disease (CKD) affects mineral metabolism, particularly focusing on phosphate, calcium, and parathyroid hormone levels. It aims to improve patient outcomes by using a systems biology approach combined with artificial intelligence to tailor treatments based on individual responses. By identifying distinct phenotypic subsets of CKD-Mineral Bone Disorder (MBD), the research seeks to optimize therapeutic strategies for better management of these conditions. The study emphasizes the importance of personalized medicine in addressing the complexities of CKD-MBD.
Why it matters
Potential benefit: If successful, this research could lead to improved management of bone and mineral disorders in CKD patients, potentially reducing cardiovascular risks and enhancing survival rates.
How similar studies have gone: Previous research has shown promise in using systems biology and artificial intelligence to improve treatment outcomes in complex medical conditions, suggesting potential for success in this approach.
Where this research is happening
-
VA North Texas Health Care System
Dallas, United States Active
Researchers
- Principal investigator: Lederer, Eleanor D — VA North Texas Health Care System
- Study coordinator: Lederer, Eleanor D
Related research
Other NIH-funded projects on the same topics.
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Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
-
Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
-
Malaria-related kidney injury and its link to chronic kidney disease in children
This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
-
Boosting self-care and physical activity for older adults with chronic kidney disease
This program helps older adults with chronic kidney disease build the skills, confidence, and motivation to be more physically active.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.