Understanding and improving symptoms of lower urinary tract dysfunction
Official title: LURN II: Enhanced Characterization of Patients with LUTS Using Biopsychosocial Approaches
Funded at University of Chicago · NIH-11122742 · Data updated 2026-11-12
This study is looking to better understand lower urinary tract symptoms (LUTS) by grouping patients with similar experiences and finding new ways to measure these symptoms, while also exploring biological samples to identify potential markers that could help distinguish between different types of patients.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | March 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $249,397 |
| NIH project number | 7U01DK097779-12 |
| Project ID | NIH-11122742 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing lower urinary tract symptoms, regardless of severity.
✕Less likely to help
Patients without any symptoms of lower urinary tract dysfunction are unlikely to benefit from this research.
What this research studies
This research aims to enhance our understanding of lower urinary tract symptoms (LUTS) by identifying distinct patient subtypes and improving how these symptoms are measured. It utilizes a consensus clustering approach based on self-reported data from patients, which helps in recognizing novel clusters of LUTS that are clinically relevant. Additionally, the study will analyze biological samples to uncover potential protein biomarkers that could differentiate between various subgroups of patients. By integrating patient experiences with clinical data, the research seeks to provide a more comprehensive view of LUTS.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment options for patients suffering from lower urinary tract symptoms.
How similar studies have gone: Previous research within the LURN network has shown promise in identifying patient subtypes and improving symptom measurement, indicating a foundation for continued success.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Griffith, James William — University of Chicago
- Study coordinator: Griffith, James William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.