Understanding and improving memory in patients with temporal lobe epilepsy
Closed-Loop Modulation of Hippocampal-Cortical Communication in Temporal Lobe Epilepsy
This study is looking at how problems with brain communication can impact memory in people with temporal lobe epilepsy, and it hopes to find ways to improve memory by fixing these communication issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11115484 on NIH RePORTER |
What this research studies
This research investigates how disruptions in brain communication affect memory in patients with temporal lobe epilepsy (TLE). By studying animal models, the researchers aim to understand the mechanisms behind long-term memory impairment caused by interictal epileptic discharges. They will explore ways to restore normal communication between brain regions involved in memory consolidation, potentially leading to new treatments that could enhance memory function in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with temporal lobe epilepsy who experience long-term memory impairment.
Not a fit: Patients without temporal lobe epilepsy or those whose cognitive impairments are unrelated to epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve memory and cognitive function in patients with temporal lobe epilepsy.
How similar studies have performed: While the specific approach of closed-loop modulation in this context is novel, similar studies have shown promise in understanding and treating cognitive impairments related to epilepsy.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Gelinas, Jennifer — University of California-Irvine
- Study coordinator: Gelinas, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.