Understanding and Improving Lung Injury from World Trade Center Exposure
Metabolomics of World Trade Center-Lung Injury: Biomarker Validation, Longitudinal Assessment and Dietary Intervention
This project looks at how exposure to World Trade Center dust affects lung health and explores if diet changes can help.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11082187 on NIH RePORTER |
What this research studies
We are exploring how exposure to World Trade Center dust leads to lung injury by looking at various biological markers in the body. This includes examining metabolic changes, gut bacteria, and genetic information to understand the disease better. We also want to see if a special diet, supported by technology, can help improve lung function and overall well-being for those affected. Our goal is to find new ways to diagnose, predict, and manage lung problems related to this exposure.
Who could benefit from this research
Good fit: Ideal candidates would be individuals who were exposed to World Trade Center particulate matter and have developed or are at risk of developing WTC-Lung Injury, particularly those with metabolic syndrome risk factors.
Not a fit: Patients whose lung injury is not related to World Trade Center exposure or who do not have metabolic syndrome risk factors may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier diagnosis, better predictions of disease progression, and new dietary approaches to improve lung health and quality of life for those with WTC-related lung injury.
How similar studies have performed: While the comprehensive multi-omics approach combined with dietary intervention for WTC-LI is novel, previous work has shown that metabolic markers can predict WTC-LI, and nutritional interventions can improve metabolic syndrome risk factors.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Nolan, Anna — New York University School of Medicine
- Study coordinator: Nolan, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.