Understanding and improving kidney transplant rejection responses
Acute Antibody Mediated Kidney Allograft Rejection
This study is looking at how special immune cells called memory T cells behave during kidney transplants to help find better ways to prevent rejection and improve transplant success for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10909120 on NIH RePORTER |
What this research studies
This research investigates how certain immune cells, particularly memory T cells, respond during kidney transplants and can lead to acute rejection. By studying the mechanisms behind these immune responses, the researchers aim to develop better strategies to manage and improve transplant outcomes. The approach involves using animal models to simulate human transplant scenarios and analyze the effects of specific treatments on immune cell behavior. The ultimate goal is to enhance the effectiveness of therapies that prevent rejection while minimizing the risks of over-immunosuppression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are undergoing or have undergone kidney transplantation and are at risk for acute rejection.
Not a fit: Patients who have not received a kidney transplant or those with other unrelated medical conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved kidney transplant outcomes and reduced rates of rejection for patients.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in transplant settings, indicating that this approach has potential for success.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Fairchild, Robert L — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Fairchild, Robert L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.