Understanding and improving brain stimulation for depression treatment
Invasive decoding and stimulation of altered reward computations in depression
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10889967
This study is looking at how we can improve treatment for depression by using special brain stimulation techniques, and it's designed for people who have epilepsy and also struggle with depression, helping to create personalized treatment plans based on their unique brain activity.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10889967 on ClinicalTrials.gov |
What this research studies
This research investigates how to better understand and treat depression by using advanced brain stimulation techniques. It focuses on collecting detailed brain activity data from patients undergoing neurosurgery for epilepsy, who also experience depression. By analyzing this data with machine learning, the goal is to create personalized treatment plans that target the specific neural mechanisms involved in each patient's depression. This approach aims to enhance the effectiveness of deep brain stimulation therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with epilepsy who also experience symptoms of depression.
Not a fit: Patients with depression who do not have epilepsy or are not candidates for neurosurgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for individuals suffering from depression.
How similar studies have performed: Other research has shown promise in using advanced brain stimulation techniques for treating depression, but this approach is innovative in its use of high-quality invasive data and machine learning.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAEZ, IGNACIO — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: SAEZ, IGNACIO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.